Crystal structure of the flavin-dependent thymidylate synthase Thy1 from Thermus thermophilus with an extra C-terminal domain

Ogawa, A.; Sampei, G.; Kawai, G.

doi:10.1107/S2053230X19007192

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
Crystal structure of TtThy1. (a) Overall structure of TtThy1. The CTDs are indicated by arrows. The four subunits are coloured orange, blue, tan and green. (b) Secondary-structure diagram of a subunit of TtThy1. The CTD (residues 223–270) is indicated in red. (c) Superposition of the structures of TtThy1 (orange) and TmThy1 (blue; PDB entry 4gtb). Two phosphate ions are located in the dUMP-binding site in the crystal structure of TtThy1. One phosphate ion overlaps with the 5′-phosphate group and the other phosphate ion overlaps with the uracil base of dUMP.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 75| Part 6| June 2019| Pages 450-454

https://doi.org/10.1107/S2053230X19007192

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