Crystal structure of the MIF4G domain of the Trypanosoma cruzi translation initiation factor EIF4G5

Camillo dos Santos, L.P.; de Matos, B.M.; de Maman Ribeiro, B.C.; Zanchin, N.I.T.; Guimarães, B.G.

doi:10.1107/S2053230X19015061

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
Superposition of TcEIF4G5-MIF (blue) and S. cerevisiae EIF4G1-MIF (ScEIF4G1-MIF; orange) in complex with eIF4A (brown; PDB entry 2vsx). (a) Overall superposition. The HEAT repeats 1, 2 and 5 involved in the ScEIF4G1–eIF4A interaction are indicated. The inset highlights the orientation change of helices 5a and 5b between the two structures. (b) Detail of the MIF4G residues involved in the ScEIF4G1–eIF4A interaction. Helices 1a and 1b are indicated. The corresponding residues in TcEIF4G5-MIF are indicated in parentheses.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 75| Part 12| December 2019| Pages 738-743

https://doi.org/10.1107/S2053230X19015061

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