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Figure 1
The two bacterial biosynthetic pathways to branched α-glucan (glycogen). (a) The well known GlgA-dependent pathway uses ADP-glucose (ADPG) as the building block for the polymerase (for example in E. coli). (b) The configuration of the pathway in M. tuberculosis, which lacks GlgA. The recently discovered GlgE pathway uses α-maltose-1-phosphate (M1P) as the building block for the polymerase. One route to this building block is via GlgM (GT4), a homologue of GlgA (GT5). G6P, glucose-6-phosphate; G1P, glucose-1-phosphate; UDPG, UDP-glucose; T6P, trehalose-6-phosphate. The figure is adapted from Koliwer-Brandl et al. (2016 ![]() |