Structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway

Schmitz, R.A.; Dietl, A.; Müller, M.; Berben, T.; Op den Camp, H.J.M.; Barends, T.R.M.

doi:10.1107/S2053230X20005294

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
The multistep reaction catalysed by DapA. The catalytic Lys162 is condensed with pyruvate, forming an enamine that reacts with L-aspartic semialdehyde (ASA). The resulting covalent intermediate is cyclized, resulting in the production of (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 76| Part 5| May 2020| Pages 199-208

https://doi.org/10.1107/S2053230X20005294

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