Figure 3
Substrate-binding region. (a) The monomers of BDH (with acetate; green) amd PDB entries 1e6w (rat HADH II/ABAD + estradiol; cyan), 3o03 (Streptococcus Ga5DH + gluconate; magenta) and 6ihh (Ralstonia cyclodiketone reductase + ethyl secodione; yellow) are superimposed and shown as wire models, along with the active-site-bound ligands, which are shown as thin sticks. The NAD from AtQR (gray) and the modeled camphor (blue) are shown as thick sticks. The BDH helices are labeled. (b) The cofactor- and substrate-binding region of BDH is shown in a close-up view. Amino-acid side chains surrounding the substrate are shown as thin sticks. |