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Figure 3
14-3-3–peptide complexes before and after soaking 14-3-3–cJun-pS227 crystals with a different peptide. (a) The 14-3-3–cJun-pS227 complex before soaking with another peptide. After soaking with another peptide, structures were solved for 14-3-3–peptide complexes containing the (b) SOS1-pS1161, (c) MLF1-pS32, (d) PLN-pS16, (e) CaMKK2-pS100, (f) caspase-2-pS164, (g) H+-ATPase-pT955, (h) CaMKK2-pS511, (i) Gab2-pS210, (j) Gab2-pT391 and (k) caspase-2-pS139 peptides. Peptides are represented by yellow sticks. 14-3-3 is represented by a white, solid surface. The 2Fo − Fc electron-density maps (represented by a blue mesh) around the peptides are contoured at 1σ. |
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