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Figure 4
Comparison of the Switch I and II regions of GDP-bound LdRab5a and GDP-bound or GppNHp-bound HsRab5a. (a) Overlap of GDP-bound LdRab5a with GDP-bound form A of HsRab5a, showing the G2 loops containing the Switch I regions as tubes. The side chains of residues that correspond between the two superimposed chains are linked by dashed lines. (b) GDP-bound LdRab5a superimposed with GppNHp-bound HsRab5a, showing the G2 loop regions as tubes. (c) GDP-bound LdRab5a superimposed with GDP-bound HsRab5a, showing the Switch II and helix α2 regions as tubes. (d) GDP-bound LdRab5a superimposed with GppNHp-bound HsRab5a, showing the Switch II region and helix α2 as tubes. Color scheme: green, LdRab5a G2 loop; violet, HsRab5a G2 loop; marine, Switch II and helix α2 of LdRab5a; salmon, Switch II and helix α2 of HsRab5a; yellow, GDP of LdRab5a; orange, GDP/GppNHp of HsRab5a. |