Crystal structure of the GDP-bound GTPase domain of Rab5a from Leishmania donovani

Zohib, M.; Maheshwari, D.; Pal, R.K.; Freitag-Pohl, S.; Biswal, B.K.; Pohl, E.; Arora, A.

doi:10.1107/S2053230X20013722

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 6
Superimposition of GDP-bound and GppNHp-bound Rab structures. Superimposition and enlarged views of the LdRab5a–GDP (green), PfRab5a–GDP (magenta), Ypt51–GppNHp (blue) and HsRab5a–GppNHp (cyan) structures. (a) Superimposition with expansion of the G2 loop showing the Switch I (SwI) and family-specific (⁴⁴TTIGAAF⁵⁰) regions of the GDP-bound LdRab5a and PfRab5a structures and the GppNHp-bound Ypt51 and HsRab5a structures. (b) Superimposition with expansion of the Switch II (SwII) and helix α2 regions of GDP-bound LdRab5a and PfRab5a and of GppNHp-bound Ypt51 and HsRab5a.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 76| Part 11| November 2020| Pages 544-556

https://doi.org/10.1107/S2053230X20013722

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