 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 2]](no5185fig2mag.jpg)
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Figure 2
Comparison of the HER3d4–DARPin D5 complex with other structures. DARPin D5 is shown as a transparent blue surface and HER3d4 as a gray cartoon. (a) Superposition on the full-length HER3 ECD (PDB entry 1m6b) shown as a cartoon in wheat. To improve clarity, domains 1 and 3 are sketched. Domains are labeled d1–d4. (b) Superposition on the extended HER1–EGF complex (PDB entry 3njp), shown as wheat and light pink cartoons. The HER1 domains d1–d3 and EGF are sketched as dashed circles. (c) Superposition on the HER3–MOR09825 complex (PDB entry 4p59). The Fab fragment MOR09825 is shown as a light green cartoon and the cognate HER3 is in wheat, where the protruding loop from domain 2 and the entire domain 3 are depicted as a surface and a cartoon, respectively. (d) Superposition of HER3d4–DARPin D5 colored as in Fig. 1 ![[link]](../../../../../../logos/arrows/f_arr.gif) (e) on the protruding loop 7 from HER1 (PDB entry 3njp, wheat) and HER4 (PDB entry 3u9u, light pink). Amino-acid numbering refers to HER3d4–DARPin D5. The superposition is based on all domain 4 residues, but only loop 7 is depicted for the sake of clarity. |
![[Figure 2]](no5185fig2.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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