Roles of the hydroxy group of tyrosine in crystal structures of Sulfurisphaera tokodaii O6-methylguanine-DNA methyltransferase

Kikuchi, M.; Yamauchi, T.; Iizuka, Y.; Tsunoda, M.

doi:10.1107/S2053230X21011055

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
Close-up of active-site cleavage in StoMGMTs. (a) Wild^m, (b) Y91F, (c) C120S, (d) C120S–O⁶-mdG, (e) Y91F/C120S and (f) Y91F/C120S–O⁶-mdG. The loop region between β5 and H8 is shown as a transparent structure. C, O and S atoms in the side chains of Tyr91 (Phe91) and Cys120 (Ser120) are colored cyan, red and yellow, respectively. Omit F_o − F_c difference maps (blue mesh), calculated without the methyl group (a), sulfo group (b), O⁶-mdG (d) and O⁶-mdG (f), are contoured at 2σ, 2σ, 2σ and 1σ, respectively.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 77| Part 12| December 2021| Pages 444-451

https://doi.org/10.1107/S2053230X21011055

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