Figure 2
(a) Monomer structure of BpSDR (PDB entry 5ig2) in a ternary complex with NAD and acetate. NAD binds in the cofactor-binding cavity, while acetate from the crystallization solution is in the substrate-binding site. The monomer is rainbow-colored from the N-terminus (blue) to the C-terminus (red). (b) Surface representation of the monomer structure of BpSDR. (b) is in the same view as (a) and shows access tunnels to the cofactor-binding cavity. (c) Topology of BpSDR. Helices are represented as cylinders, strands as arrows and loops as blue lines. The amino-terminus is labeled N and the carboxyl-terminus is labeled C. |