 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 3]](no5188fig3mag.jpg)
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Figure 3
Comparison of representative SDRs with BpSDR. (a) SDRs have a well conserved NAD-binding region and a variable substrate-binding region which determines their specificity. The PDB codes for the monomers are 6g41 (light orange), 2jap (light blue), 4yai (green), 1fmc (teal) and 5ig2 (black). (b) Side-by-side comparison of the NAD-binding domains of BpSDR (PDB entry 5ig2) with its closest structural neighbor the Rv0851c ortholog short-chain dehydrogenase from M. paratuberculosis (PDB entry 3tjr) reveal conserved residues involved in hydrogen bonds (dashed green lines); the hydrophobic interactions that predominate in the NAD-binding domain are shown as red arcs with lines. Corresponding atoms that are involved in hydrophobic contacts are shown in red circles. |
![[Figure 3]](no5188fig3.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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