Figure 2
Structures of PPARδ LBD–ligand complexes. (a) Overall view of the complexes. PPARδ LDB is shown as a ribbon representation colored from blue (N-terminus) to red (C-terminus). Omit Fo − Fc electron-density maps for (b) TIPP-204, (c) JKPL38, (d) JKPL39 and (e) JK122 are shown contoured at 3.0σ. Ligands are shown as stick models. C atoms of TIPP-204, JKPL38, JKPL39 and JK122 are colored yellow, cyan, green and violet, respectively. All atomic models were generated by PyMOL (https://www.pymol.org). |