Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative

Oyama, T.; Takiguchi, K.; Miyachi, H.

doi:10.1107/S2053230X22000449

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
Ligand binding to PPARδ LBD. (a) Structure of PPARδ LBD–TIPP-204. A comparison is shown of the previous (gray) and current high-resolution (yellow) structures. Different conformations are indicated by arrows. (b) Superposition of PPARδ LBD in complexes with TIPP-204 (yellow), JKPL38 (cyan) and JKPL39 (green). The arm 2 groove is represented by a transparent surface. An arrow indicates the bottom of arm 2. (c) Structure comparison of PPARδ LBD–TIPP-204 (yellow) and PPARδ LBD–JK122 (violet). The branch butoxy residue and the tail trifluoromethylbenzyl residue shift slightly (about 0.8 Å) towards arms 2 and 3, respectively, compared with the corresponding parts of TIPP-204 (indicated by arrows).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 78| Part 2| February 2022| Pages 81-87

https://doi.org/10.1107/S2053230X22000449

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