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Figure 12
(a) P. falciparum NADP+–6PGDH complex (PDB entry 6fqy). (b) Human NADPH–6PGDH complex (PDB entry 2jkv). Ligands are shown in sphere mode in (a) (two NADP+ and two ethanediol molecules) and in only one of the homodimers in (b) (one NADPH molecule, two sulfate ions and two chloride ions in green). (c) Overlay of one homodimer from PDB entry 2jkv (gold) with NADPH bound in both subunits onto that from PDB entry 6fqy (pale blue), showing a 3.5 Å opening of the coenzyme domain in the left subunit of PDB entry 2jkv when both subunits are overlaid at the right. (c) was prepared in CCP4mg (McNicholas et al., 2011BB77).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 78| Part 3| March 2022| Pages 96-112
https://doi.org/10.1107/S2053230X22001091
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