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Figure 9
Envisioned figurative model of how 6PGDH works. The two subunits are depicted in different colours. Two possible conformations, symmetrical and asymmetrical, are represented. In the asymmetrical configuration one subunit has the coenzyme-binding domain rotated compared with the other domain, allowing entrance/release of the coenzyme. Red arrows indicate transitions between the symmetrical and asymmetrical 6PGDH conformations. Ligands functioning as decarboxylation and Ru5P-binding activators are shown in red. The two structures outlined in yellow have both subunits involved in catalysis: one in the redox reaction and the other in decarboxylation.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 78| Part 3| March 2022| Pages 96-112
https://doi.org/10.1107/S2053230X22001091
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