Figure 1
(a) Cartoon representation of one LmPTR1 subunit, showing the typical Rossmann fold. Secondary-structure elements are colored green (helix), blue (strand) and pink (loop) and are labeled. The cofactor NADP(H) and substrate folate (FOL) are represented as orange and green sticks, respectively. (b, c) 2Fo − Fc electron-density map contoured at 1.5σ of the folate and His241 in chain A (blue mesh) and in chain C (pink mesh). The catalytic triad residues (Asp181, Tyr194 and Lys198) are also shown as cyan sticks. This figure was generated using PyMOL and CCP4mg. |