Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)

Guarino, S.R.; Di Bello, A.; Palamini, M.; Capillo, M.C.; Forneris, F.

doi:10.1107/S2053230X22003855

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
Structural comparison of hROR1-KRD with KRDs from related ROR1/2 structures. (a) Comparison of hROR1-KRD with related kringle domains: the most relevant deviations were found in the two consecutive turns encompassing the Phe347–Gly358 region (black dashed circle). ROR1 structures from PDB entries 5z55 (marine), 6ba5 (dark blue, cyan, sky blue and purple-blue for the four chains in the asymmetric unit) and 6ban (green forest, split pea and lime green for the four chains in the asymmetric unit) and ROR2 structures from PDB entries 6osh (orange), 6osn (magenta) and 6osv (pink) are shown. (b) Superposition of the structures of ROR1 and ROR2 KRDs in complex with therapeutic antibody fragments (orange for ROR1 and green for ROR2) reveals the presence of two juxtaposed epitopes located on the domain surface.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 78| Part 5| May 2022| Pages 185-192

https://doi.org/10.1107/S2053230X22003855

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