Crystal structure of an extracellular superoxide dismutase from Onchocerca volvulus and implications for parasite-specific drug development

Moustafa, A.; Perbandt, M.; Liebau, E.; Betzel, C.; Falke, S.

doi:10.1107/S2053230X22005350

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
High-resolution crystal structure of OvEC-SOD. (a) Topology diagram of the protein and its secondary structure. (b) Superposition of O. volvulus SOD (green) with T. solium SOD (pink; PDB entry 3mnd; C^α r.m.s.d. of 0.5 Å; Hernández-Santoyo et al., 2011

) and H. sapiens SOD (purple); PDB entry 1hl4; C^α r.m.s.d. of 0.5 Å; Strange et al., 2003

). (c) Cartoon and surface representation of the crystallographic OvEC-SOD dimer. The approximate position of the active site as highlighted in (d) is framed. (d) Close-up of the active site and the two conserved metal ions. The coordination distances are shown in Å.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 78| Part 6| June 2022| Pages 232-240

https://doi.org/10.1107/S2053230X22005350

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