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Figure 2
Sequence alignment of parts of ATP-citrate lyase (ACLY) and succinyl-CoA synthetase (SCS) showing the conservation of the glutamate residue Glu599 of ACLY. Crystal structures have been determined of the enzymes shown. While human ACLY is a homotetramer, ACLY from Chlorobium limicola is a heterooctamer and the equivalent residue is in the A subunit. Human GTPSCS is a heterodimer, while E. coli and Thermus aquaticus SCS are heterotetramers; however, the similar residue is in the α-subunit in all cases.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 78| Part 10| October 2022| Pages 363-370
https://doi.org/10.1107/S2053230X22008810
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