Figure 2
(a) Overlay of NPC1-C with NPC1-C–EBOV GP (PDB entry 5f1b) and NPC1-C–NPC2 (PDB entry 5kwy). The dashed oval indicates the location of the N-terminal helix, which is unfolded in our structure. (b) Overlay of NPC1-C with the crystal structure of the glycosylated form of NPC1-C (PDB entry 5hns). The N- and C-termini are labeled N and C, respectively. |