A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations

Doamekpor, S.K.; Peng, P.; Xu, R.; Ma, L.; Tong, Y.; Tong, L.

doi:10.1107/S2053230X23002224

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 4
Closed conformation of the H875Y/F877L/T878A and F877L/T878A mutants. (a) Overlay of the structures of the human AR LBD H875Y/F877L/T878A triple mutant in complex with DHT (PDB entry 8fh0; orange) and the AR LBD F877L/T878A double mutant in complex with DHT (PDB entry 8fh1; pink) with that of wild-type AR LBD in complex with DHT (gray; PDB entry 2ama; Pereira de Jésus-Tran et al., 2006

). (b) Semi-transparent surface of the ligand-binding cavity in the F877L/T878A double mutant.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 79| Part 4| April 2023| Pages 95-104

https://doi.org/10.1107/S2053230X23002224

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