Drastic alterations in the loop structure around colchicine upon complex formation with an engineered lipocalin indicate a conformational selection mechanism

Jerschke, E.; Eichinger, A.; Skerra, A.

doi:10.1107/S2053230X23006817

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 4
Schematic illustration of the principle of conformational selection upon the binding of colchicine to Colchicalin. Prior to complex formation, Colchicalin exists in solution in at least two states, one with an open and one with an occluded ligand pocket, and only the open state can accommodate colchicine.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 79| Part 9| September 2023| Pages 231-239

https://doi.org/10.1107/S2053230X23006817

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