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Figure 3
Examples of inter-chain differences in local alternate conformations. These examples demonstrate the differences in side-chain conformations between chains A (cyan) and B (maroon). (a) Overlay of chains A and B, highlighting the locations of the residues displayed in (b)–(d). (b) Phe182 of the WPD loop adopts a different conformation in each chain (2Fo − Fc map in blue mesh, 1σ). (c) The allosteric loop 11 (Keedy et al., 2018BB30) is flexible in chain A but is more ordered in chain B (2Fo − Fc map in blue mesh, 0.5σ; Fo − Fc map shown as green/red volume, ±3σ; alternate conformation A in cyan and B in teal). (d) Gln262 of the active-site Q loop adopts a single conformation in chain A but alternate conformations in chain B (2Fo − Fc map in blue mesh, 0.75σ; Fo − Fc map shown as green/red volume, ±3σ; alternate conformation A in maroon and B in salmon).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 80| Part 1| January 2024| Pages 1-12
https://doi.org/10.1107/S2053230X23010749
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