 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 4]](jt5072fig4mag.jpg)
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Figure 4
Unexpected differences in the allosteric L16 site involving loop 16, the N-terminus and the C-terminus. (a) Comparison of PTP1B in the closed state (PDB entry 1sug, dark blue) and in the open state bound to an allosteric inhibitor at the nearby BB site (PDB entry 1t49, green) shows large changes in the regions constituting the allosteric L16 site. (b) An overlay of the two chains in our new structure (cyan, chain A; maroon, chain B) shows more subtle but significant differences in the three regions of the L16 site. (c) Two structures in the P43212 ligand-bound series (PDB entry 8g6a chain A, olive; PDB entry 8g67 chain A, orange; Greisman, Willmore et al., 2023  ) show little to no change in the three regions. (d) Two other structures in the P43212 ligand-bound series (PDB entry 8g69 chain A, dark red; PDB entry 8g65 chain A, brown; Greisman, Willmore et al., 2023) show a uniquely reordered C-terminus as well as changes in loop 16. |
![[Figure 4]](jt5072fig4.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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