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Figure 5
Modeling missing alternate conformations for a high-resolution double-mutant structure. A cluster of residues centered around and including the point mutations F225Y and R199N in a high-resolution (1.24 Å) double-mutant structure of PTP1B (PDB entry 7mn9; Torgeson et al., 2022BB51) exhibits difference electron-density features suggestive of unmodeled alternate conformations. Original conformations are in pink; manually modeled alternate conformations are in brown. (a) Zoomed-out view of the residues displayed in subsequent panels. (b) Original model from PDB entry 7mn9 (2Fo − Fc map in blue mesh, 1σ; Fo − Fc map in green/red meshes, ±3σ). (c) Updated model with manually modeled missing alternate conformations (2Fo − Fc map in blue mesh, 1σ; Fo − Fc map in green/red meshes, ±3σ).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 80| Part 1| January 2024| Pages 1-12
https://doi.org/10.1107/S2053230X23010749
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