Figure 3
Close-up view of the overlaid structures of the ICD–SB505124 and ICD–SB431542 complexes, showing the compound interactions in the ATP-binding cleft and the residues contacting either SB505124 or SB431542. Colour code: ICD–SB505124 (PDB entry 9f6x), blue and yellow; ICD–SB431542 (PDB entry 3mtz), emerald and jade. Hydrogen bonds are shown as black dashed lines. |