Figure 5
LigPlus-generated interaction plots show conserved catalytic cavity residues. Structures are shown of (a) HpBPL with biotinyl-5-ATP (PDB entry 6ck0), (b) HpBPL with biotinyl-5-ATP (PDB entry 6ck0) superposed with MtBPL with a nucleoside-based bisubstrate adenylation inhibitor (PDB entry 4xu1) and (c) MtBPL with a nucleoside-based bisubstrate adenylation inhibitor (PDB entry 4xu1). |