Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody

Semwal, S.; Karamolegkou, M.; Flament, S.; Raouraoua, N.; Verstraete, K.; Thureau, A.; Wien, F.; Bray, F.; Savvides, S.N.; Bouckaert, J.

doi:10.1107/S2053230X24012159

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 6
Overlay of SRCD spectra of Mannitou Fab conformations. Five `peak A' Fab samples (dark brown to dark blue) and two `peak B' Fab samples (light green and black) are shown, as well as the monomer Fab from peak A transitioned from 20 to 80°C in only 3 min (cyan). There is a shift to the left with a loss of antiparallel β-sheet structure.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 1| January 2025| Pages 19-29

https://doi.org/10.1107/S2053230X24012159

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