 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 3]](cha5001fig3mag.jpg)
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Figure 3
Structural and sequence alignments of class 2 dihydroorotate dehydrogenases show high conservation in the active site. (a) Dihydroorotate dehydrogenase (DHODH) from H. pylori (PDB entry 6b8s chain A) is depicted in light green, that from E. coli (PDB entry 1f76 chain A) is depicted in light pink, that from M. tuberculosis (PDB entry 4xq6 chain B) is depicted in light blue, that from P. falciparum (PDB entry 5boo chain A) is depicted in red and that from H. sapiens (PDB entry 2prm chain A) is depicted in dark blue. Flavin mononucleotide (FMN) is shown (yellow ball-and-stick representation) as an overlay from H. pylori DHODH. (b) Class 2 DHODHs have a well conserved FMN binding region. The view is rotated 90° from (a) to (b). (c) The ConSurf alignment shows strong conservation near the FMN binding site. ConSurf analysis was carried out with default parameters using PDB entry 6b8s chain A. Flavin mononucleotide (FMN) is shown (yellow ball-and-stick representation). The view is rotated 90° along a diagonal from (b) to (c). |
![[Figure 3]](cha5001fig3.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
