LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

Kim, Y.; Knapp, S.; Krämer, A.

doi:10.1107/S2053230X25000913

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 2
ITC curves of suramin binding to human (a) and murine (b) TRIM21 PRYSPRY domains. Titration heats of each injection (upper panel) and normalized binding heats (lower panel) are shown. The parameters of a nonlinear least-squares fit of the binding isotherm to a single, reversible binding-site model are shown in the image for each titration.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 3| March 2025|

https://doi.org/10.1107/S2053230X25000913

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