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Figure 2
Structural alignment of MeGH168 with the Fun168A product complex provides insight into its active site. (a) Complete alignment of MeGH168 (cyan) and Fun168A (PDB entry 8ya7, pink) shown in cartoon representation. MeGH168 loop regions that are structurally variable in comparison to Fun168A are shown in navy. (b) Active-site catalytic residues of MeGH168 (cyan) compared with Fun168A (PDB entry 8ya7, pink). (c) Residues in negative subsites (−1, −2) of MeGH168 (cyan) compared with Fun168A (PDB entry 8ya7, pink). (d) Residues in suggested positive subsites (+1, +2, +3) of MeGH168 (cyan) compared with Fun168A (PDB entry 8ya7, pink). The fucoidan tetrasaccharide ligand is represented in green sticks.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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