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Figure 3
Example of five crystallization wells shown with brightfield (left), UV-TPEF (middle) and second-harmonic generation (SHG) SONICC images of successful crystallization screening using different types of imaging modalities. Even when protein crystals are obscured by precipitate, UV-TPEF and SHG images can assist with the identification of potentially promising crystal hits. These imaging methods also assist with the identification of microcrystals and nanocrystals.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 81| Part 7| July 2025| Pages 272-280
https://doi.org/10.1107/S2053230X25004650
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