 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 1]](uf5017fig1mag.jpg)
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Figure 1
Fascin1-mediated actin bundling in tumor-cell protrusions. (a) Schematic representation of tumor cells forming membrane protrusions during tumor progression. The black dashed box highlights an individual tumor cell, where these protrusions emerge. The purple dashed box provides a closer view of the actin filaments, showing how fascin1 cross-links them into tightly packed bundles via its actin-binding sites. (b) Structural representation of fascin1, shown in two orientations rotated 180° along the displayed axis. The four β-trefoil domains (labeled 1–4) are shown, with actin-binding sites (green) located at distinct regions. Key post-translational modifications involved in fascin1 regulation are also indicated: phosphorylation sites (red) and ubiquitination sites (yellow). |
![[Figure 1]](uf5017fig1.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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