 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 1]](us5161fig1mag.jpg)
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Figure 1
MenD catalytic cycle illustrating the formation of several ThDP-bound covalent intermediates from sequential reaction with the substrates 2-oxoglutarate (intermediate I) and isochorismate (intermediate II), resulting ultimately in regeneration of the ThDP and release of the product SEPHCHC. Note that the aminopyrimidine ring is shown in its AP (4′-aminopyrimidine) tautomer form in ThDP and intermediate I and its IP (1′,4′-iminopyrimidine) tautomer form in intermediate II; shuttling of tautomer states is important during the catalytic cycle. |
![[Figure 1]](us5161fig1.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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