PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning

Costa-Gomes, B.; Greer, J.; Juraschko, N.; Parkhurst, J.; Mirecka, J.; Famili, M.; Rangel-Smith, C.; Strickson, O.; Lowe, A.; Basham, M.; Burnley, T.

doi:10.1107/S2053230X25007575

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
Flowchart of the overall pipeline utilizing profet, EMPIARreader and CAKED. Data can be retrieved from the preferred source with profet (and then, for example, input into a simulator to achieve a synthetic image populated with the structure) and EMPIARreader allows lazy loading of the data from the specified directory; further processing can then be performed with CAKED, which will collate the data ready to feed to a machine-learning model. The green ovals correspond to the inputs, purple rectangles to the implemented packages, the blue rectangle to the outside sources and yellow ovals to the output.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 10| October 2025| Pages 441-450

https://doi.org/10.1107/S2053230X25007575

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