Crystal structure of a short-chain dehydrogenase from Brucella ovis with apo and coenzyme NAD+-bound protomer chains

Zupko, S.P.; Konstanty, A.T.; Mayclin, S.J.; Choi, R.; Serbzhinskiy, D.; Robles, E.; Moses, V.; Barrett, L.K.; Van Voorhis, W.C.; Edwards, T.E.; Myler, P.J.; Torelli, A.T.; French, J.B.; Hicks, K.A.

doi:10.1107/S2053230X25009227

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

IUCr IT WDC

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Figure 1
SDR-catalyzed reaction. The substrate(s) for BoSDR are unknown. However, these enzymes are short-chain dehydrogenases (SDRs), which are NAD(P)-dependent oxidoreductase enzymes. These enzymes are involved in both the oxidation of alcohols (example reaction shown above with R referring to the rest of the molecule) and the reduction of ketones, often with broad substrate specificities (Roth et al., 2018