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Figure 1
Classification and analysis of sirtuin PSSM results for potential 14-3-3 phosphoserine binding sites. Peptides with a gray background were not analyzed experimentally. Score is the overall PSSM score for the phosphorylation site; rank is the order within the 17 proposed sirtuin binding sites. Conserved residues in the 14-3-3 motifs are marked in green. Residues with restricted (proline) or very flexible (glycine) protein backbone or with a very large side chain (tryptophan) are marked in red. Amino acids with the same or similar hydrophobicity/size are shown in magenta. Kd values from duplicate measurements are colored green for Kd < 100 µM. Fields marked in red indicate no binding or no successful experiment.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 82| Part 1| January 2026| Pages 32-40
https://doi.org/10.1107/S2053230X25010908
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