 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 3]](rl5206fig3mag.jpg)
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Figure 3
Comparison of the interactions in the active site between MjDHOase and EcDHOase (PDB entry 1xge; Lee et al., 2005  ). MjDHOase is in tan and EcDHOase is in light green. The coloring of the labels is black for MjDHOase and green for EcDHOase. (a) Only interactions involving CA are shown for clarity. CA is at the center. The figure illustrates the high similarity of the active site in MjDHOase and EcDHOase. (b) Interactions of the two residues at the tip of the flexible loop with the protein residues nearby, illustrating the correspondence of some of the interactions and the larger number of interactions in EcDHOase compared with MjDHOase (see also Supplementary Table S2). Hydrogen bonds are indicated by dashed lines. Protein residues that make also contacts of ≤4.0 Å are indicated. The Cα backbones of the two flexible loops are included. Thr109 and Thr110 in EcDHOase form three hydrogen bonds (Thr109 N⋯Ser112 OG, The110 OG1⋯Ala266 O and Asn44 ND2⋯Thr110 O), and Thr109 makes contacts with Tyr104, Leu222 and His139. The corresponding Ser143 and Val144 in MjDHOase form two hydrogen bonds (Asn89 ND2⋯Val144 O and Asn275 ND2⋯Ser143 OG) and contacts with His168 and His306, respectively. |
![[Figure 3]](rl5206fig3.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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