Cryo-EM structures of a MexB–MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain

Wang, J.; Tsutsumi, K.; Hirose, M.; Nakashima, R.; Kato, T.; Nishino, K.; Nakagawa, A.; Yamashita, E.

doi:10.1107/S2053230X26001202

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 3
Comparison of the FL domain between MexB, MexY, MexBYB-Ka-supplemented I and MexBYB-Ka-supplemented II. The side view and the top view of (a) MexB (EMDB entry EMD-10371), (b) MexY (EMDB entry EMD-47796), (c) MexBYB-Ka-supplemented I and (d) MexBYB-Ka-supplemented II are shown. An equilateral triangle, with the side length defined by connected reference points on protomers A and C (corresponding to protomers in the extrusion and binding states in MexY and to protomers in the close and tight states in MexB), was generated in red dotted lines in each FL domain.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 82| Part 3| March 2026| Pages 83-93

https://doi.org/10.1107/S2053230X26001202

Open

access

Follow Acta Cryst. F

Search IUCr Journals		doi		Advanced search
Author		volume	page