Cryo-EM structures of a MexB–MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain

Wang, J.; Tsutsumi, K.; Hirose, M.; Nakashima, R.; Kato, T.; Nishino, K.; Nakagawa, A.; Yamashita, E.

doi:10.1107/S2053230X26001202

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 4
Overlay diagram of MexBYB-Ka-supplemented I and MexY protomers. (a, b, c) Protomers A, B and C of MexBYB-Ka-supplemented I (pink) fitted on protomers A, B and C of MexY (EMDB entry EMD-10371; gray) by aligning PC2. (d, e, f) Protomers A, B and C of MexBYB-Ka-supplemented I (pink) fitted on protomers A, B and C of MexY (EMDB entry EMD-10371; gray) by aligning PN1. The side view of the protomer and the top view of the porter domain are shown and significant changes are indicated by a dashed circle in red.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 82| Part 3| March 2026| Pages 83-93

https://doi.org/10.1107/S2053230X26001202

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