Figure 1
The PvMIF monomer. (a) Cartoon representation of a PvMIF monomer colored in rainbow from blue at the N-terminus to red at the C-terminus. (b) Superposed monomers of PDB entry 9b0m (gray) with PDB entries 9mf3 (lemon green), 2wkf (magenta), 4p7m (tan), 3gac (wheat), 2wkb (cyan), 4dh4 (slate blue), 8ap3 (orange), 8ur2 (green), 8vj2 (smudge green) and 2xcz (yellow), the orthologues identified by ENDScript that were used to generate the sausage plot (Dobson et al., 2009 ; Pantouris et al., 2014 ; Shao et al., 2010 ; Sommerville et al., 2013 ; Spiller et al., 2023 ; Srivastava et al., 2024 ; Kimble et al., 2024 ; Wasiel et al., 2010 ). (c) PvMIF sausage plot generated by ENDScript. The ribbon (sausage) shows the relative conservation of secondary structure compared with the closest MIF structures. The ribbon thickness reflects the degree of secondary-structure similarity, with thinner ribbons indicating more conserved regions and thicker ribbons indicating lower conservation, as determined by r.m.s.d. alignment of the structures in (c). The ribbon is colored based on sequence conservation, with red indicating identical residues (a), (b) and (c) show the same view and orientation of PvMIF. The C-terminus and N-terminus are indicated by C and N, respectively. |