Crystal structures of PCNA1 and PCNA2 from Aeropyrum pernix: implications for a distorted heterotrimeric sliding clamp

Wang, T.; Ishino, S.; Ishino, Y.; Oyama, T.

doi:10.1107/S2053230X26003687

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 4
Proposed structural model of the A. pernix PCNA heterotrimer. (a) Model of the ApePCNA1–ApePCNA2–ApePCNA3 heterotrimer constructed using the ApePCNA2 homotrimer as a template. Subunits are replaced with ApePCNA1 (cyan) and an ApePCNA3 model (orange). The cis-peptide is shown as yellow sticks. (b) Stereo pair of a close-up view of the clashing region between ApePCNA1 and ApePCNA2, viewed from the direction indicated by the arrow in (a). Arg188 causes a steric clash with ApePCNA2. (c) Schematic diagram of the predicted ApePCNA heterotrimer. The threefold rotational symmetry is predicted to be broken by the cis-peptide protrusion (yellow triangle) of ApePCNA1.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 82| Part 6| June 2026| Pages 216-221

https://doi.org/10.1107/S2053230X26003687

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