Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

Mima, M.; Mishima-Tsumagari, C.; Sakata-Sakuta, M.; Iwaoka, R.; Iwamoto, K.

doi:10.1107/S2053230X26003432

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
Docking simulation model of the vornorexant–OX₁R complex. (a) Overall structure of the vornorexant–OX₁R complex. The OX1R molecule is shown in magenta and vornorexant is shown in yellow using a CPK space-filling model. (b) Binding mode of vornorexant within OX₁R. Vornorexant and the interacting residues of OX₁R are represented as stick models, with C atoms in yellow (vornorexant) and magenta (OX₁R) color. Hydrogen bonds are indicated by green dotted lines.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 82| Part 6| June 2026| Pages 201-207

https://doi.org/10.1107/S2053230X26003432

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