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Figure 4
Comparison of the binding modes of antagonists to the orexin receptors. Superimposed crystal structures showing the binding modes of vornorexant (yellow) to OX2R (blue), compared with (a) lemborexant (deep blue) in the lemborexant–OX2R complex (PDB entry 7xrr) and (b) suvorexant (orange) in the suvorexant–OX2R complex (PDB entry 4s0v). Hydrogen bonds are indicated by green dotted lines. |

journal menu![[Figure 4]](pg5098fig4.jpg)
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