Recombinant versus native botulinum neurotoxin type A: structural and pharmacodynamic comparison

Yao, Z.; Xu, L.; Lu, Y.; Gong, H.; Sun, X.; Zhao, Y.; Chen, J.; Yang, L.; Chen, Q.; Yang, W.

doi:10.1107/S2053230X26009830

Figure 1
Overall structure of rBoNT/A. (a) Schematic depiction of the engineered domain organization of rBoNT/A. (b) CE–SDS analysis of rBoNT/A under nonreducing conditions (top) and reducing conditions (bottom). (c) Different view of the 3D reconstruction and cartoon representation of rBoNT/A, with each subunit individually colored (LC in blue, H_N in red and H_C in green).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 82| Part 11| November 2026| Pages 391-401

https://doi.org/10.1107/S2053230X26009830

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