Recombinant versus native botulinum neurotoxin type A: structural and pharmacodynamic comparison

Yao, Z.; Xu, L.; Lu, Y.; Gong, H.; Sun, X.; Zhao, Y.; Chen, J.; Yang, L.; Chen, Q.; Yang, W.

doi:10.1107/S2053230X26009830

Figure 2
Structural comparison of rBoNT/A with BoNT/A in its open and closed conformations. (a) Side view of the superimposition of rBoNT/A (LC in blue, H_N in red and H_C in green) and BoNT/A_{open/apo/pH7.0} (PDB entry 3bta, wheat) when they are aligned at the LC domain. (b) Side view of the superimposition of rBoNT/A (LC in blue, H_N in red and H_C in green) and BoNT/A_{closed/SV2B-bound/pH5.5} (PDB entry 9f2y, pink) when they are aligned at the LC domain. Green–pink arrows indicate the rotation of the H_C domain.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 82| Part 11| November 2026| Pages 391-401

https://doi.org/10.1107/S2053230X26009830

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