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Figure 2
(a) Elution profiles of UV280 and SAXS I0 and Rg over the elution peak of the sample solution of TTR–tolcapone (1:10). The arrow indicates the region of the tetramer (N = 4). (b) Global and (c) local comparison of the SWAXS profiles of the TTR solutions, with tolcapone and tafamidis (R = 10) (SASBDB entry codes SASDXX3 and SASDXY3). The data are fitted (with the χ2 indicated) using CRYSOL with the crystal structures 3tct and 8aww of TTR–tafamidis and 4d7b of TTR–tolcapone. (d) and (e) Same sets of SWAXS data fitted using WAXSis. Arrows in (c) and (e) mark the regions of larger fitting deviations.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 58| Part 4| August 2025| Pages 1373-1383
https://doi.org/10.1107/S1600576725004716
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