Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC-SWAXS and NMR

Shih, O.; Feng, Y.-C.; Agrawal, S.; Liao, K.-F.; Yeh, Y.-Q.; Chang, J.-W.; Yu, T.-Y.; Jeng, U.-S.

doi:10.1107/S1600576725004716

Journal of Applied Crystallography Journal of Applied
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Figure 5
(a) Independent SEC elution profile (3 µl injection) of UV₂₈₀ for TTR in 8 M urea at 37°C, showing multiple peaks (indicated by arrows) of TTR oligomers. (b) SEC-SAXS elution profiles (10 µl injection) of I₀, R_g, and aggregation number N deduced over the two major elution peaks P1 and P2 in (a). (c) Corresponding SWAXS profiles of the same two major species, P1 and P2 of Apo-TTR, with the R_g values indicated.

JOURNAL OF
APPLIED
CRYSTALLOGRAPHY

ISSN: 1600-5767

Volume 58| Part 4| August 2025| Pages 1373-1383

https://doi.org/10.1107/S1600576725004716

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