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Figure 7
(a) SEC-SWAXS elution profiles of SAXS I0 and Rg for TTR with tafamidis at the binding ratio R = 1, in an incubated sample solution of 8 M urea, measured at 37°C. (b) Parallel result for TTR–tolcapone. (c) Corresponding SEC-SWAXS profile of TTR–tafamidis (1:1). For comparison, the SWAXS profile calculated using CRYSOL with the crystal structure 4d7b of tafamidis–TTR is also shown (solid curve).

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